Mucuna Extract,L-dopa

Production Name:Mucuna Pruriens Extract

Latin Name:Mucuna cochinchine-sis(Lour)Tang et Wang

Part: Seed (Dried, 100% Natural

Active Ingredient: Levodopa (L-dopa)

Extraction Method: Water/ Grain Alcohol

Form: white powder

Specification: 5%-98%

Test Method :HPLC

CAS No.59-92-7

Molecular formal: C9H11NO4

Molecular weight:197.19

Solubility:Good solubility in hydro-alcoholic solution

Description of Mucuna Extract,L-dopa

What is Mucuna Pruriens and L-DOPA

Mucuna pruriens is a shrub which uses it vines as support to climb and grow. When Mucunapruriens are young

they are covered with hair which disappears as the plant gets old.The plant growswell in tropical areas of India,

West Indies and Africa. The leaves of Mucuna pruriens are of variousshapes like ovate, tripinnate and rhombus

shape.

Mucuna Pruriens Extract is anti-paralysis agitans. Through the blood-brain barrier into the braintissue, but by the

decarboxylation of dopa decarboxylase into dopamine,play a role.

L-DOPA is used to increase dopamine concentrations in the treatment of PD and DRD, since it iscapable of

crossing the protective blood-brain barrier (BBB), whereas dopamine itself cannot. Once L-DOPA has entered the

central nervous system (CNS), it is converted into dopamine by the enzymearomatic L-amino acid decarboxylase

(AADC), also known as DOPA decarboxylase (DDC).Pyridoxal phosphate (PLP; Vitamin B6) is a required cofactor

in this reaction, and may occasionallybe administered along with L-DOPA, usually in the form of pyridoxine.

Extraction Process :

Raw materials(Mucuna Pruriens) → Crushing → Extract→ Concentrate → Precipitation→ Refining → Drying → Standard production

The main difference between synthetic levodopa and natural extract levodopa:

Synthetic levodopa contains D-DOPA but natural extract levodopa does not contain, which can be tested by HPLC.

How does L-dopa work in Parkinson’s disease

Mucuna pruriens extract contains levodopa (L-dopa), which is used to treat Parkinson's disease. L-dopa is

changed to the chemical dopamine in the brain. Symptoms of Parkinson's disease occur in patients due to low

levels of dopamine in the brain. Unfortunately, most L-dopa is broken down in the body before it ever reaches the

brain unless special chemicals are used with levodopa. These chemicals are not present in Mucuna pruriens

extract. L-DOPA from mucuna pruriens has been shown to be safer and more effective for controlling Parkinson's

disease than the pharmaceutical drugs Levodopa and Carbidopa. This is because the vast array of other chemical

constituents that accompany L-DOPA in the unprocessed plant also play a role in its ability to manage Parkinson's

disease.

How does L-dopa work in hair growth

1 .Amino acids- made up of carbon, hydrogen, oxygen and nitrogen- serve as the foundation of protein. One type of

protein, keratin, makes up about 88 percent of each strand of hair on your body. Of the 23 total types of amino acids

, five of them -- arginine, cystine, cysteine, lysine and methionine -- particularly encourage healthy hair growth.

2.Methionine, cysteine and arginine support healthy hair and protect against hair loss by reducing oxidative stress

and restoring hormonal balances.

3.Several publications indicate that the amino acid arginine has an enormous effect on hair growth. As a precursor

to nitrogen oxide, it is of vital importance for hair growth. The vasodilatory effect of arginine promotes hair growth as

the nitrogen oxide generated from arginine opens the potassium channels of the cells.

Function of Mucuna Extract,L-dopa

1.Mucuna Pruriens Extract can be used as dietary supplements.

2.Mucuna Pruriens Extract is used as a component in marine adhesives used by pelagic life.

3.Mucuna Pruriens Extract can promote muscle growth,loss weight,and increased bone density and reversal of osteoporosis.

4.Mucuna Pruriens Extract increase bone density and reversal of osteoporosis,increase muscle strength,enhance libido and sexual performance.

5.In clinical use, Mucuna Pruriens Extract is administered in the management of Parkinson's disease and dopa-responsive dystonia.

6.For essential tremor and paralysis paralysis agitans syndrome of non-drug immunogenicity, and in better light, severe, or the elderly poor.

7.Treat parkinsonism and Pakinsonism syndrome, hepatic coma,hub functions to improve the patient awake, symptom improvement.

8.Mucuna Pruriens Extract is anti-paralysis agitans. Through the blood-brain barrier into the brain tissue, but by the decarboxylation of l-dopa decarboxylase into dopamine, play a role.

9.Mucuna Pruriens Extract is used for essential tremor and paralysis paralysis agitans syndrome of non-drug immunogenicity, and in better light, severe, or the elderly poor.

Application of Mucuna Extract,L-dopa

1.Mucuna Pruriens Extract can be used as dietary supplements.

2.Mucuna Pruriens Extract is used as a component in marine adhesives used by pelagic life.

3.Mucuna Pruriens Extract can promote muscle growth,loss weight,and increased bone density and reversal of osteoporosis.

4.Mucuna Pruriens Extract increase bone density and reversal of osteoporosis,increase muscle strength,enhance libido and sexual performance.

5.In clinical use, Mucuna Pruriens Extract is administered in the management of Parkinson's disease and dopa-responsive dystonia.

6.For essential tremor and paralysis paralysis agitans syndrome of non-drug immunogenicity, and in better light, severe, or the elderly poor.

7.Treat parkinsonism and Pakinsonism syndrome, hepatic coma,hub functions to improve the patient awake, symptom improvement.

8.Mucuna Pruriens Extract is anti-paralysis agitans. Through the blood-brain barrier into the brain tissue, but by the decarboxylation of l-dopa decarboxylase into dopamine, play a role.

9.Mucuna Pruriens Extract is used for essential tremor and paralysis paralysis agitans syndrome of non-drug immunogenicity, and in better light, severe, or the elderly poor.

Q&A:

1.Are you a manufacturer or trade company
We have our own factory which located in Zhejiang,China.Meanwhile,we also have many parter factorier,so we can supply many kinds of relative products with very competitive price and good quality.

2.How  to start an order

After negoation and communication about the price,quantity,incoterm,etc.,you give me the order contract with stamp,then I sealed it ,send back to you,also give you the proforma invoice,you can arrange the payment according the PI.

3.What’s your payment terms

If sample,small amount: T/T in advance, ,Paypal.
If commercial order ,big amount: T/T in advance,L/C at sight.

4.Can I get a free sample

If this product is not very expensive,and you demand a small sample,we can supply free sample,but not including the shipping cost,you can provide a freight collect account or arrange the shipping cost by Paypal/Westunion.

5.What's the lead time
Generally we send out your order ASAP after payment,normally

small quanitity,3-5days.

big quanitity with stock,5-7days,

if without stock,we have to calculate the production period,then give you the lead tme.

6.How do you ship the order normally

If less than 50kg,will be shipped by express,such as FEDEX,DHL.

If above 50kg,we can ship it by air or sea
For very large quantity,ship it by sea will be the best choice.

7.How do you ensure the quality of your products
Strict QC with 6 steps testing from raw material purchase to finished product.

Meanwhile,we will responsible for the goods quality after be sold.