Camptothecin

Botanical Name: Fructus Camptothecae Acuminatae

Part of Used: Fruit

Specification:  98%,99%

Appearance: Yellow fine powder

Active ingredients: Camptothecin

Testing Method: HPLC

CAS No.: 7689-03-4

Mol. Formula: C20H16N2O4

Mol. Weight: 348.35

Description of Camptothecin

What is Camptotheca acuminata

The Happy Tree, Cancer Tree, or Tree of Life (Camptotheca acuminata) is a genus of medium-sized deciduous treesgrowing to 20 m tall, native to southern China and Tibet. They are usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae. Camptotheca is used to make Irinotecan,Topotecan, 9-Aminocamptothecin, and camptothecin-1 (CPT-1). It also contains trifolin and hyperoside.

What is Camptotheca acuminata Extract Camptothecin

Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to Chinaused as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminaryclinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancerchemotherapy today, topotecan and irinotecan.

Where will Camptotheca acuminata Extract Camptothecin be used for

1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.

2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.

3. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.

4. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

Function of Camptothecin

1.Camptothecine Powder can make changes in skin epidermal keratinization process.

2.Camptothecine Powder is used for anti-cancer, anti-virus, immune inhibition, anti early pregnancy.

3.Camptothecine Powder has the function of treatment of gastric cancer, liver cancer, head and neck cancer and leukemia.

Application of Camptothecin

1. Treatment Gastrointestinal cancer and leukemia,

2. Plant growth regulator activity and kill insects.

3. Treatment of gastric cancer, liver cancer, head and neck cancer and leukemia,, with fewer side effects than camptothecine

Q&A:

1.Are you a manufacturer or trade company
We have our own factory which located in Zhejiang,China.Meanwhile,we also have many parter factorier,so we can supply many kinds of relative products with very competitive price and good quality.

2.How  to start an order

After negoation and communication about the price,quantity,incoterm,etc.,you give me the order contract with stamp,then I sealed it ,send back to you,also give you the proforma invoice,you can arrange the payment according the PI.

3.What’s your payment terms

If sample,small amount: T/T in advance, ,Paypal.
If commercial order ,big amount: T/T in advance,L/C at sight.

4.Can I get a free sample

If this product is not very expensive,and you demand a small sample,we can supply free sample,but not including the shipping cost,you can provide a freight collect account or arrange the shipping cost by Paypal/Westunion.

5.What's the lead time
Generally we send out your order ASAP after payment,normally

small quanitity,3-5days.

big quanitity with stock,5-7days,

if without stock,we have to calculate the production period,then give you the lead tme.

6.How do you ship the order normally

If less than 50kg,will be shipped by express,such as FEDEX,DHL.

If above 50kg,we can ship it by air or sea
For very large quantity,ship it by sea will be the best choice.

7.How do you ensure the quality of your products
Strict QC with 6 steps testing from raw material purchase to finished product.

Meanwhile,we will responsible for the goods quality after be sold.